This month’s issue contains updates on the stats, the data and the science of the many facets of the COVID-19 pandemic, including the direct and indirect consequences of the disease and the decisions that have been made along the way, and the COVID-19 vaccines. This issue is larger than usual (173 pages). There is so much high-quality and critically important information coming at us at such a rate, that it is so hard for me to exclude vital stories. The good news is that you can let me do all the work for you as I attempt to compile the best of the best.